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Cell signalling and vesicular trafficking

Understanding how cells move together



Collective cell migration plays a fundamental role during the development of pluricellular organisms and in wound healing, it is also involved in the dissemination of cancer cells during metastasis formation. Our overarching goal is to understand the molecular mechanisms regulating collective cell movements.


How do border cells coordinate their movements to perform an invasive migration in Drosophila egg chambers ?


What are the molecular regulators of vesicular trafficking that localize key determinants of cell migration during collective cell movements ?


Are the same mechanisms involved in border cell migration regulating the migration of cancer cells during metastasis formation ?



Present lab members



Directing with restraint: Mechanisms of protrusion restriction in collective cell migrations. GM Roberto, Emery G, Semin Cell Dev Biol . 2022 Sep;129:75-81. doi: 10.1016/j.semcdb.2022.03.037.

Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission. Iannantuono, NVG,  Emery G, Chen J. Journal of Cell Science. 2021 Jun 15;134(12):jcs244384. doi: 10.1242/jcs.244384

Temporal Coordination of Collective Migration and Lumen Formation by Antagonism between Two Nuclear Receptors. Wang X, Wang H, Liu L, Li S, Emery G, Chen J. iScience. 2020 Jul 24;23(7):101335. doi: 10.1016/j.isci.2020.101335

The ArfGAP Drongo Promotes Actomyosin Contractility during Collective Cell Migration by Releasing Myosin Phosphatase from the Trailing Edge. Zeledon C., Sun X., Plutoni C., Emery G., Cell Reports. 2019 Sep 17; 28(12):3236-3248.

Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration. Plutoni C, Keil S, Zeledon C, Delsin LEA, Decelle B, Roux PP, Carréno S, Emery G. Nat Commun. 2019 Sep 2;10(1):3940.


Non-autonomous role of Cdc42 in cell-cell communication during collective migration.

Colombié N, Choesmel-Cadamuro V, Series J, Emery G, Wang X, Ramel D. Dev. Biol. 2017-03-01;423(1):12-18.

Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis.

Laflamme C, Galan JA, Ben El Kadhi K, Méant A, Zeledon C, Carréno S, Roux PP, Emery G. Mol. Cell. Biol. 2017-02-01;37(3).

ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential.

Frémin C, Guégan JP, Plutoni C, Mahaffey J, Philips MR, Emery G, Meloche S. Oncogene 2016-10-27;35(43):5692-5698.

Spatial regulation of greatwall by Cdk1 and PP2A-Tws in the cell cycle.

Wang P, Larouche M, Normandin K, Kachaner D, Mehsen H, Emery G, Archambault V. Cell Cycle 2016-02-16;15(4):528-39.

In Vitro and In Vivo Characterization of the Rab11-GAP Activity of Drosophila Evi5.

Laflamme C, Emery G. Methods Mol. Biol. 2015-01-01;1298:187-94.

Cell coordination of collective migration by Rab11 and Moesin.

Emery G, Ramel D. Commun Integr Biol 2013-07-01;6(4):e24587.

GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation.

Fernández-Espartero CH, Ramel D, Farago M, Malartre M, Luque CM, Limanovich S, Katzav S, Emery G, Martín-Bermudo MD. J. Cell. Sci. 2013-05-15;126(Pt 10):2285-93.

Rab11 regulates cell-cell communication during collective cell movements.

Ramel D, Wang X, Laflamme C, Montell DJ, Emery G. Nat. Cell Biol. 2013-03-01;15(3):317-24.


Evi5 promotes collective cell migration through its Rab-GAP activity.

Laflamme C, Assaker G, Ramel D, Dorn JF, She D, Maddox PS, Emery G. J. Cell Biol. 2012-07-09;198(1):57-67.

Proteomic Profiling of the TRAF3 Interactome Network Reveals a New Role for the ER-to-Golgi Transport Compartments in Innate Immunity.

van Zuylen WJ, Doyon P, Clément JF, Khan KA, D'Ambrosio LM, Dô F, St-Amant-Verret M, Wissanji T, Emery G, Gingras AC, Meloche S, Servant MJ. PLoS Pathog. 2012-07-01;8(7):e1002747.


The unexpected role of Drosophila OCRL during cytokinesis.

Ben El Kadhi K, Emery G, Carreno S. Commun Integr Biol 2012-05-01;5(3):291-3.


The inositol 5-phosphatase dOCRL controls PI(4,5)P2 homeostasis and is necessary for cytokinesis.

Ben El Kadhi K, Roubinet C, Solinet S, Emery G, Carréno S. Curr. Biol. 2011-06-21;21(12):1074-9.


Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration.

Assaker G, Ramel D, Wculek SK, González-Gaitán M, Emery G. Proc. Natl. Acad. Sci. U.S.A. 2010-12-28;107(52):22558-63.

Emery - lab 2022


Postal Address

IRIC | Université de Montréal
P.O. Box 6128, Downtown Station
Montréal, Québec H3C 3J7

Address for deliveries

IRIC | Université de Montréal
2950, Chemin de Polytechnique
Pavilion Marcelle-Coutu, Dock 20
Montréal, Québec  H3T 1J4

On-Campus Address

Pavilion Marcelle-Coutu
2950, Chemin de Polytechnique


Tel: +1 514 343 6111 - ext. 0318

Want to join the lab?

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